Expert Video - Which genetic mutations and cytogenetic changes have a more favorable response to MDS treatment?
Prof. Valeria Santini, an expert on MDS from the University of Florence, discusses what we currently know about genetic mutations and cytogenetic changes associated with better myelodysplastic syndromes (MDS) treatment outcomes. For example, changes in chromosome 5 (some 5q deletions) can indicate a favorable response to treatment with lenalidomide. A mutation in the gene SF3B1 can also indicate a good prognosis. Prof. Santini discusses the need for transfusion and the role of multiple mutations.
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Other Modules:
Animation - Understanding Genetic Mutations in MDS
Slide Show - Understanding Genetic Mutations in MDS
1.
What is a genetic mutation, a biomarker, and cytogenetic analysis in MDS?
2.
Why is understanding genetic mutations and cytogenetics in MDS important?
3.
Is an MDS-related genetic mutation something I was born with or something that occurred later on?
4.
How do my genetic mutations influence MDS risk?
5.
How does genetic testing help in MDS diagnosis?
6.
How is genetic testing for MDS carried out?
7.
Which genetic mutations and cytogenetic changes have a more favorable response to MDS treatment?
8.
Which genetic mutations and cytogenetic changes have a less favorable response to MDS treatment?
9.
Which MDS genetic mutations are most likely to cause relapse?
10.
What questions should I ask my doctor about MDS genetic testing?
11.
Becky's story: What is your MDS gene mutation profile? When and how were you tested for it?
12.
Donna's story: What is your MDS gene mutation profile? When and how were you tested for it?
13.
Holly's story: What is your MDS gene mutation profile? When and how were you tested for it?
14.
Becky's story: What advice do you have for other MDS patients about genetic testing?
15.
Donna's story: What advice do you have for other MDS patients about genetic testing?
16.
Holly's story: What advice do you have for other MDS patients about genetic testing?
