Module: Understanding Myelodysplastic Syndromes

Understanding Myelodysplastic Syndromes
This animation provides an overview of myelodysplastic syndromes (MDS), and describes the causes, risk factors, symptoms, and different types of MDS. It also explains the role of bone marrow to produce blood cells (red blood cells, white blood cells, and platelets) and what happens to normal bone marrow in MDS.
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Module: Understanding MDS-related Anemia

Understanding MDS-related Anemia
This animation provides an overview of myelodysplastic syndromes (MDS) and MDS-related anemia, including the causes, common symptoms, and diagnosis. It also describes the different types of MDS, risk scores, and explains that the disease can range in its severity.
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Module: Understanding Erythropoiesis

Understanding Erythropoiesis
This animation explains erythropoiesis, which is the term for the production of red blood cells. Red blood cells, called erythrocytes, carry oxygen around your body. This animation explains the erythrocyte life cycle and describes how a low red blood cell count causes anemia. Anemia typically results from bleeding, red blood cell destruction, or decreased red blood cell production by the bone marrow, as seen in disorders such as myelodysplastic syndromes (MDS). The animation describes treatments for a low red blood cell count, including medications, blood transfusions, and stem cell transplant.
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Module: Diagnosis of MDS

Diagnosis of MDS
This animation explains the tests that doctors use to diagnose myelodysplastic syndromes (MDS), including blood cell counts, blood cell examination, and bone marrow tests. It also describes the symptoms associated with low blood cell counts, MDS overlap syndromes, classification of MDS subtypes, and scoring systems used to estimate the severity of MDS.
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Module: Understanding Genetic Mutations in MDS

Understanding Genetic Mutations in Myelodysplastic Syndromes (MDS)
MDS is very different from person to person, so learning your mutation profile is important. Knowing what mutations you have can help you and your doctor understand how you are likely to be affected by your MDS, including how you will respond to certain treatments. Watch to learn about genetic changes in myelodysplastic syndromes (MDS), and the many different driver mutations that are associated with MDS. Some mutated genes are associated with lower-risk disease, while others may indicate greater risk. Your mutation profile can change over time so it is important to repeat the testing at different stages of your treatment. The more you know about your genetic makeup in MDS, the more you will understand the outlook and in some cases, the treatment that is most likely to be effective.
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Module: Management and Treatment of MDS

Management and Treatment of MDS
This animation explains the current treatment approaches for myelodysplastic syndromes (MDS). Treatment options are grouped into 3 main types: observation, supportive care, and disease-modifying treatment. The animation also describes the goals of treatment for low-risk versus high-risk MDS, as well as clinical trials.
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Module: Managing and Treating MDS-related Anemia

Managing and Treating MDS-related Anemia
This animation explains the current management and treatment approaches for MDS-related anemia. It provides an overview of blood transfusions, medicines to increase red blood cell production, chemotherapy, future treatments, and bone marrow (stem cell) transplant. Treatment for MDS-related anemia depends on several factors including what type of MDS you have, your general health, your age, your risk score, and what you want for the future.
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Module: Mutation-Driven Therapy in MDS

Mutation-Driven Therapy in MDS
Mutation-driven therapy is treatment based on the mutations, or changes, in your genes. Knowing what mutations you have helps your doctor predict how your body will respond to MDS treatment. In fact, it can help them choose a treatment that targets your specific mutations. Watch to learn how mutation-driven therapy works, the genetic mutations commonly found in myelodysplastic syndromes (MDS), and the importance of genetic testing for these mutations. If you are diagnosed with MDS, it is important to ask about testing. Knowledge about your MDS-related genetics can lead to more successful treatment.
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Module: Blood and Marrow Transplantation in MDS

Blood and Marrow Transplantation in MDS
This animation provides an overview of blood and marrow transplantation (BMT) for myelodysplastic syndromes (MDS). Doctors also call BMT a stem cell transplant or hematopoietic stem cell transplant. This animations explains how BMT works, who is eligible, and what to expect before, during, and after the procedure.
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This educational activity has been developed by the Myelodysplastic Syndromes Foundation, Inc. and Mechanisms in Medicine Inc.

This activity is supported by an educational grant from Acceleron Pharma, Bristol-Myers Squibb, Celgene Corporation, Jazz Pharmaceuticals, Novartis Pharmaceuticals, and Takeda Oncology.

This website is part of the Animated Patient™ series developed by Mechanisms in Medicine Inc., to provide highly visual formats of learning for patients to improve their understanding, make informed decisions, and partner with their healthcare professionals for optimal outcomes.